Recent Publications



Microindentation for in vivo Measurement of Bone Tissue Mechanical Properties in Humans
Adolfo Diez-Perez, Roberto Güerri, Xavier Nogues, Enric Cáceres, Maria Jesus Peña, Leonardo Mellibovsky, Connor Randall, Daniel Bridges, James C. Weaver, Alexander Proctor, Davis Brimer, Kurt J. Koester, Robert O. Ritchie, Paul K. Hansma
Journal of Bone and Mineral Research. Vol 25 No 8. (2010)


Reference Point Indentation (RPI) Instrument: Laboratory and Clinical Case-Control Studies (ORS Poster)
Hansma, P K; Randall, C; Bridges, D B; Weaver, J; Guerri, R C; Nogues, X; Diez-Perez A
Orthopedic Research Society Poster 2010


Bone Diagnostic Instrument III
Connor Randall, Phillip Mathews, Eugene Yurtsev, Nadder Sahar, David Kohn, and Paul Hansma
Review of Scientific Instruments 80, 065108 (2009)


Tissue Diagnostic Instrument
Paul Hansma, Hongmei Yu, David Schultz, Azucena Rodriguez, Eugene A. Yurtsev, Jessica Orr, Simon Tang, Jon Miller, Joseph Wallace, Frank Zok, Cheng Li, Richard Souza, Alexander Proctor, Davis Brimer, Xavier Nogues-Solan, Leonardo Mellbovsky, M. Jesus Pe–a, Oriol Diez-Ferrer, Phillip Mathews, Connor Randall, Alfred Kuo, Carol Chen, Mathilde Peters, David Kohn, Jenni Buckley, Xiaojuan Li, Lisa Pruitt, Adolfo Diez-Perez, Tamara Alliston, Valerie Weaver, and Jeffrey Lotz
Review of Scientific Instruments 80, 054303 (2009)


The bone diagnostic instrument II: Indentation distance increase
Paul Hansma, Patricia Turner, Barney Drake, Eugene Yurtsev, Alexander Proctor, Phillip Mathews, Jason Lelujian, Connor Randall, Jonathan Adams, Ralf Jungmann, Federico Garza-de-Leon, Georg Fantner, Haykaz Mkrtchyan, Michael Pontin, Aaron Weaver, Morton B. Brown, Nadder Sahar, Ricardo Rossello, and David Kohn
Review of Scientific Instruments 79, 064303 (2008)


Bone Diagnostic Instrument
Paul K. Hansma, Patricia J. Turner, Georg E. Fantner
Review of Scientific Instruments 77, 075105 (2006)


Sacrificial Bonds and Hidden Length: Unraveling Molecular Mesostructures in Tough Materials
Georg E. Fantner, Emin Oroudjev, Georg Schitter, Laura S. Golde, Philipp Thurner, Marquesa M. Finch, Patricia Turner, Thomas Gutsmann, Daniel E. Morse, Helen Hansma, Paul K. Hansma.
Biophysical Journal, 90 (4): 1411. (2006)


Hierarchical interconnections in the nano-composite material Bone: Fibrillar Cross-Links resist fracture on several length scales
Georg E. Fantner, Olexandr Rabinovych, Georg Schitter, Philipp Thurner, Johannes H. Kindt, Marquesa M. Finch, James C. Weaver, Laura S. Golde, Daniel E. Morse, Everett A Lipman, Ivo W. Rangelow, Paul K Hansma
Comp. Sci. Tech. (advance publication online, December 2005)


Components for High Speed Atomic Force Microscopy
Georg E Fantner, Georg Schitter, Johannes H. Kindt, Tzvetan Ivanov, Katarina Ivanova, Rohan Patel, Niels Holten-Andersen, Jonathan Adams, Philipp J. Thurner, Ivo W. Rangelow and Paul K. Hansma
Accepted, Ultramicroscopy, 2006


High-Speed Photography of the Development of Microdamage in Trabecular Bone During Compression
Philipp J. Thurner, Blake Erickson, Zachary Schriock, John Langan, Jeff Scott, Maria Zhao, James C. Weaver, Georg E. Fantner, Patricia Turner, Johannes H. Kindt, Georg Schitter, Daniel E. Morse, Paul K. Hansma
Accepted to Journal of Materials Research, January 2006


High Speed Photography of Compressed Human Trabecular Bone Correlates Whitening to Microscopic Damage
P. Thurner, B. Erickson, Z. Schriock, J.C. Weaver, G.E. Fantner, G. Schitter, J.H. Kindt, P. Turner, D.E. Morse, P.K. Hansma
Submitted to Engineering Fracture Mechanics, 1/11/06


Design and Modeling of a High-Speed Scanner for Atomic Force Microscopy
Georg Schitter, Karl J. Åström, Barry DeMartini, Georg E. Fantner, Kimberly Turner, Philipp J. Thurner, and Paul K. Hansma
Accepted, American Control Conference 2006


Sacrificial bonds in the interfibrillar matrix of bone
Paul K. Hansma, Georg E. Fantner, Johannes H. Kindt, Philipp J. Thurner, Georg Schitter, Patricia J. Turner, Simcha F. Udwin, Marquesa M. Finch
J Musculoskelet Neuronal Interact 2005; 5(4):313-315


A new technique for imaging Mineralized Fibrils on Bovine Trabecular Bone Fracture Surfaces by Atomic Force Microscopy
Johannes H. Kindt, Georg E. Fantner, Philipp J. Thurner, Georg Schitter, Paul K. Hansma
Mater. Res. Soc. Symp. Proc. Vol. 874, L5.12.1


Sacrificial Bonds in Polymer Brushes from Rat Tail Tendon Functioning as Nanoscale Velcro
Thomas Gutsmann, Tue Hassenkam, Jacqueline A. Cutroni, and Paul K. Hansma
Biophysical Journal, 89 (1): 536. (2005)


High-Speed Photography of Human Trabecular Bone during Compression
Philipp J. Thurner, Blake Erickson, Zachary Schriock, John Langan, Jeff Scott, Maria Zhao, Georg E. Fantner, Patricia Turner, Johannes H. Kindt, Georg Schitter, Paul K. Hansma
Mater. Res. Soc. Symp. Proc. Vol. 874 (2005), L1.2.1


On recent developments for high-speed atomic force microscopy
Georg Schitter, Georg E. Fantner, Johannes H. Kindt, Philipp J. Thurner, Paul K. Hansma
Conference paper, IEEE/ASME International Conference on Advanced Intelligent Mechatronics, Monterey, CA, July 2005


Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture
Georg E. Fantner, Tue Hassenkam, Johannes H. Kindt, James C. Weaver, Henrik Birkedal, Jacqueline A. Cutroni, Geraldo A.G. Cidade, Galen D. Stucky, Daniel E. Morse, Paul K. Hansma
Nature Materials, (August 2005) Vol 4 (8): 612-616


Novel Techniques for High-Resolution Functional Imaging of Trabecular Bone
Philipp Thurner, Georg E. Fantner, Johannes Kindt, Manuela Venturoni, Patricia Turner, Peter Wyss, Urs Sennhauser, Ralph Muller, Paul Hansma
Medical Imaging 2005: Physics of Medical Imaging. Edited by Flynn, Michael J. Proceedings of the SPIE, Volume 5746, pp. 515-526 (2005)


A Review of Atomic Force Microscopy in Parkinson's Research
Robert D. Field and Paul K Hansma
Microscopy and Analysis Issue 65, (March 2004)


Data Acquisition System for High Speed Atomic Force Microscopy
Georg E. Fantner, Paul Hegarty, Johannes H. Kindt, Georg Schitter, Geraldo A.G. Cidade, and Paul K. Hansma
Review of Scientific Instruments 76, 026118 (2005)


Rigid design of fast scanning probe microscopes using finite element analysis
J.H. Kindt, G.E. Fantner, J.A. Cutroni, P.K. Hansma
Ultramicroscopy 100 (August 2004) 259–265


Automated wafer-scale fabrication of electron beam deposited tips for atomic force microscopes using pattern recognition
Johannes H. Kindt, Georg E. Fantner, James B. Thompson, and Paul K. Hansma
Nanotechnology (July 2004) 15 1131-1134


Influence of the Degradation of the Organic Matrix on the Microscopic Fracture Behavior of Trabecular Bone
Georg E. Fantner, Henrik Birkedal, Johannes H. Kindt, Tue Hassenkam, Bonnie L. Bosma, Jacquelin A. Cutroni, James C. Weaver, Lukmaan Bawazer, Marquesa M. Finch, Geraldo A.G. Cidade, Daniel E. Morse, Galen D. Stucky, Paul K. Hansma
Bone (November 2004), Vol. 35 (5): 1013-1022


Exploring Molecular and Mechanical Gradients in Structural Bioscaffolds
J. Herbert Waite, Helga C. Lichtenegger, Galen D. Stucky, and Paul K. Hansma
Biochemistry (June 2004) 22;43(24):7653-62.


Giant Bent-Core Mesogens in the Thread Forming Process of Marine Mussels
Tue Hassenkam, Thomas Gutsmann, Paul Hansma,Jason Sagert, and J. Herbert Waite
Biomacromolecules (June 2004) Vol. 5 (4): 1351-1355


Force Spectroscopy of Collagen Fibers to Investigate Their Mechanical Properties and Structural Organization
Thomas Gutsmann, Georg E. Fantner, Johannes H. Kindt, Manuela Venturoni, Signe Danielsen, and Paul K. Hansma
Biophysics Journal (May 2004) Vol. 86 1-8


High Resolution AFM Imaging of Intact and Fractured Trabecular Bone
T. Hassenkam, G.E. Fantner, J.A. Cutroni, J.C. Weaver, D.E. Morse, P.K. Hansma
Bone (July 2004), Vol. 35 (1): 4-10


Atomic force microscopy study of living diatoms in ambient conditions
I.C. Gebeshuber, J.H. Kindt, J.B. Thompson, Y. Del Amo, H. Stachelberger, M.A. Brzezinski, G.D. Stucky, D.E. Morse & P.K. Hansma
Journal of Microscopy (December 2003) Vol. 212 (3): 292-299


Please note that we published a corrigendum on this paper:


New Atomic Force Microscopes (AFM) for the Study of Enzymatic Properties and Processes
Johannes H. Kindt, Jackie A. Cutroni, Thomas Gutsmann, and Paul K. Hansma
AAPPS Bulletin (April 2003), Vol. 13 (2): 8-11.


Evidence that Collagen Fibrils in Tendons Are Inhomogeneously Structured in a Tubelike Manner
Thomas Gutsmann, Georg E. Fantner, Manuela Venturoni, Axel Ekani-Nkodo, James B. Thompson, Johannes H. Kindt, Daniel E. Morse, Deborah Fygenson, and Paul K. Hansma
Biophysical Journal (April 2003), Vol. 84: 2593-2598.


Investigations into the polymorphism of rat tail tendon fibrils using atomic force microscopy
Manuela Venturoni, Thomas Gutsmann, Georg E. Fantner, Johannes H. Kindt, and Paul K. Hansma
Biochemical and Biophysical Research Communications (February 2003), 303: 508-513.


Molecular nanosprings in spider capture-silk threads
Nathan Becker, Emin Oroudjev, Stephanie Mutz, Jason Cleveland, Paul Hansma, Cheryl Hayashi, Dmitrii Makarov, and Helen Hansma
Nature Materials (April 2003), Vol. 2: 278-283.


Nanostructural Features of Demosponge Biosilica
Lia I. Pietrasanta, James C. Weaver, Niklas Hedin, Brad F. Chmelka, Galen D. Stucky, Daniel E. Morse, and Paul K. Hansma
Journal of Structural Biology (2003) 144, 271-281.


Atomic force microscope detector drift compensation by correlation of similar traces acquired at different setpoints
Johannes H. Kindt, James B. Thompson, Mario B. Viani, and Paul K. Hansma
Review of Scientific Instruments (June 2002) Vol. 73 (6): 2305-2307


The Backbone Conformational Entropy of Protein Folding: Experimental Measures from Atomic Force Microscopy
James B. Thompson, Helen G. Hansma, Paul K. Hansma, and Kevin W. Plaxco
Journal of Molecular Biology(September 20, 2002); 322 (3): 645-652.


Bone Indentation Recovery Time Correlates with Bond Reforming Time
James B. Thompson, Johannes H. Kindt, Barney Drake, Helen G. Hansma, Daniel E. Morse, and Paul K. Hansma
Nature (December 13, 2001) Vol. 414:773-775


Kinetic Monte Carlo simulation of titin unfolding
Dmitrii E. Makarov, Paul K. Hansma, and Horia Metiu
Journal of Chemical Physics (June 2001) Vol. 114 (21):9663-9673


Assessing the quality of scanning probe microscope designs
James B. Thompson, Barney Drake, Johannes H. Kindt, Jessica Hoskins, and Paul K. Hansma
Nanotechnology (August 2001) Vol. 12: 394-397


Micromechanical and structural properties of a pennate diatom investigated by atomic force microscopy
N. Almqvist, Y. Delamo, B.L. Smith, N.H. Thomson, A. Bartholdson, R. Lal, M. Brzezinski, and Paul K. Hansma
Journal of Microscopy (June 2001) Vol. 202 (3): 518-531


Angular Fourier Mapping: Highlighting lattice structures without destroying original data
Johannes H. Kindt, James B. Thompson, George T. Paloczi, Martina Michenfelder, Bettye L. Smith, Galen Stucky, Daniel E. Morse, and Paul K. Hansma
Materials Research Society Symposium (2000) Vol. 620: M4.2.1-M4.2.7


Stepwise unfolding of titin under force-clamp atomic force microscopy
Andres F. Oberhauser, Paul K. Hansma, Mariano Carrion-Vazquez, and Julio M. Fernandez
PNAS (January 2001), Vol. 98 (2): 468-472


Recent Highlights from Atomic Force Microscopy of DNA
Helen G. Hansma, Lia I. Pietrasanta, Roxana Golan, John C. Stiko, Mario Viani, George Paloczi, Bettye L. Smith, Douglas Thrower, and Paul K. Hansma
Journal of Biomolecular Structure & Dynamics (1999), Conversation 11, Issue #1


Simulation of an Atomic Force Microscope Imaging a Moving Protein
S. Kasas, N. H. Thomson, T.E. Schaffer, G. Dietler, S. Catsicas and P.K. Hansma
Probe Microscopy (2000) Vol. 2: 37-44


Fluorescent apparent quantum yields for excited molecules near dielectric interfaces
Q.Q. Shu and P.K. Hansma
Thin Solid Films (2001) 384: 76-84


Direct Observation of the Transition from Calcite to Aragonite Growth as Induced by Abalone Shell Proteins
James B. Thompson, George T. Paloczi, Johannes H. Kindt, Martina Michenfelder, Bettye L. Smith, Galen Stucky, Daniel E. Morse, and Paul K. Hansma
Biophysical Journal (December 2000) Vol. 79: 3307-3312


Probing protein-protein interactions in real time
Mario B. Viani, Lia I. Pietrasanta, James B. Thompson, Ami Chand, Ilse C. Gebeshuber, Johannes H. Kindt, Michael Richter, Helen G. Hansma and Paul K. Hansma
Nature Structural Biology (August 2000) Vol. 7 (8): 644-647